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Sekisui XenoTech
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Sekisui XenoTech
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Becton Dickinson
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Gentest Corp
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Becton Dickinson
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Sekisui XenoTech
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Gentest Corp
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Simcyp
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Gentest Corp
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Gentest Corp
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Becton Dickinson
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Image Search Results
Journal: Drug metabolism and disposition: the biological fate of chemicals
Article Title: The human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation
doi: 10.1124/dmd.113.052613
Figure Lengend Snippet: Human liver microsomes (HLM) or recombinant UGT enzymes were incubated for 4 hours in the presence of 100μM bile acid substrates: chenodeoxycholic (A, CDCA), cholic (B, CA), deoxycholic (C, DCA) lithocholic (D, LCA), hyodeoxycholic (E, HDCA) and hyocholic (F, HCA) acids. The formation of bile acid-glucuronides (G) was analyzed by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Data represent the mean ± S.D. of two independent experiments performed in triplicate.
Article Snippet: Commercially available
Techniques: Recombinant, Incubation, Liquid Chromatography, Mass Spectrometry, Liquid Chromatography with Mass Spectroscopy